Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.
Bioorg Med Chem Lett
; 23(13): 3910-3, 2013 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-23683589
ABSTRACT
A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pironas
/
Sondas Moleculares
/
D-Aminoácido Oxidase
/
Inibidores Enzimáticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article