Determination of nitrogen mustard degradation products in water samples using a portable capillary electrophoresis instrument.
Electrophoresis
; 34(14): 2078-84, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23686627
ABSTRACT
In this work, a new purpose-made portable CE instrument with a contactless conductivity detector was used for the determination of degradation products of nitrogen mustards in different water samples. The capillary was coated with poly(1-vinylpyrrolidone-co-2-dimethylaminoethyl methacrylate) to avoid analyte-wall interactions. The coating procedure was studied to obtain the best repeatability of the migration time of the analytes. Four different coating procedures were compared; flushing the capillary with the copolymer at 100 psi for 2 min at 60°C provided the best RSD values (<4%). The analytical method was also optimized. The use of 20 mM of MES adjusted to pH 6.0 with His as running buffer allowed a good baseline separation of the three analytes in different water samples without matrix interferences. The method permitted the detection of the three degradation products down to 5 µM.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
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Substâncias para a Guerra Química
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Eletroforese Capilar
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Mecloretamina
Tipo de estudo:
Evaluation_studies
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article