Augmentation of mouse immune functions by dietary restriction: an investigation up to 1 year of age.
Ann Nutr Metab
; 34(2): 76-84, 1990.
Article
em En
| MEDLINE
| ID: mdl-2369077
ABSTRACT
Mice fed a 40% restricted diet until 1 year of age showed a 35% drop in body weight and markedly lower weights in the central lymphoid organs such as spleen and thymus than those of unrestricted mice. In contrast, the percentage of splenic Thy 1.2+ T cells was dramatically increased by dietary restriction. Splenic Ly 1+ T cells were also increased in the restricted mice. Spleen cells of the restricted mice revealed significantly higher responses not only in macrophage (MP)-dependent responses such as concanavalin A response and mixed-lymphocyte reaction but also in MP-independent T cell responses to recombinant interleukin 2 even at 1 year of age. These results strongly suggest that dietary restriction causes an enrichment of Thy 1.2+ T cells in spleen and augments the functions of T cells in mice.
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Base de dados:
MEDLINE
Assunto principal:
Baço
/
Linfócitos T
/
Interleucina-2
/
Privação de Alimentos
/
Imunidade
/
Distúrbios Nutricionais
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article