DNA synthesis by L929 cells following doxorubicin exposure.
Cancer Res
; 50(15): 4776-8, 1990 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-2369751
ABSTRACT
Doxorubicin does not kill L929 cells at concentrations that profoundly reduce clonogenic survival. Instead, the cell and nuclear volume progressively increase for at least 1 week following drug exposure leading to the production of characteristic giant cells. The increase in nuclear volume is due to continued DNA synthesis and increase in chromosome number without entry into mitosis. The implications of this finding for in vitro chemosensitivity assays and for the mechanism of doxorubicin cytotoxicity are discussed.
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Base de dados:
MEDLINE
Assunto principal:
DNA
/
Doxorrubicina
/
Replicação do DNA
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article