Spectrometric method for the assay of ramipril using molybdophosphoric acid.
Rev Med Chir Soc Med Nat Iasi
; 116(4): 1218-22, 2012.
Article
em En
| MEDLINE
| ID: mdl-23700915
ABSTRACT
UNLABELLED Ramipril is a drug of the angiotensin converting enzyme inhibitor class. AIM:
A new molecular absorbance spectrometric method was developed for the assay of ramipril using molybdophosphoric acid in acidic medium. MATERIAL ANDMETHODS:
The reaction product showed a maximum absorbance at 361 nm. The optimum conditions of the reaction were established. The developed method was validated.RESULTS:
The method showed a good linearity in the range of 8 - 36 microg/ml (correlation coefficient r = 0.9996). The detection limit (LD) was 0.86microg/ml and the quantification limit (LQ) 2.88 pg/ml. Precision and accuracy were determined (RSD = 1.15%); mean recovery was 98.90% in the 97.13-101.03% concentration range.CONCLUSIONS:
The proposed method is simple, easy to perform, sensitive, linear, precise, accurate and robust.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Fosfóricos
/
Espectrofotometria
/
Inibidores da Enzima Conversora de Angiotensina
/
Ramipril
/
Indicadores e Reagentes
/
Molibdênio
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article