Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder.
J Psychiatr Res
; 47(10): 1546-8, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23702250
ABSTRACT
Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis of psychiatric disordersand is related to traumatic life events. To examine serum BDNF levels, we compared one group of DSM-IV GID patients (n = 45) and one healthy control group (n = 66). Serum BDNF levels were significantly decreased in GID patients (p = 0.013). This data support the hypothesis that the reduction found in serum BDNF levels in GID patients may be related to the psychological abuse that transsexuals are exposed during their life.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transexualidade
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Fator Neurotrófico Derivado do Encéfalo
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Identidade de Gênero
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article