Correlation between microalbuminuria with complexity of coronary artery disease in diabetic patients.

ABSTRACT

The present studies found that microalbuminuria is predictive, independent of classical risk factor of cardiovascular diseases and all causes of mortality in diabetes or hypertension patient groups and in the general population. Coronary angiograms for extent of severe CAD (luminal narrowing 50%) in patients with Diabetes Mellitus (DM) and general population were examined. The study comprised 150 patients undergoing coronary angiography at United Hospital Limited, Dhaka, Bangladesh, (M/F 80/70, mean age 57±11 years). Urine albumin excretion was measured in 24 hours urine samples employing immune precipitation technique. Age-gender distribution of coronary risk factors and microalbuminuria were compared between patient with and without coronary artery disease. As many as 70.5% (106) of patient had coronary artery disease and 29.4%(44) had no coronary lesion. Microalbuminuria was detected at 62.9% in patients with CAD and 8.8% in those without coronary artery lesion (p<0.001). The presence of 1 or 2 vessel CAD showed a linear increase between the groups without microalbuminuria. Patients with microalbuminuria have more severe angiographically detected coronary artery disease than those without microalbuminuria, thus a link can be established independent of other risk factors.