A pilot study of muscle plasma protein changes after exercise.
Muscle Nerve
; 49(2): 261-6, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-23716353
ABSTRACT
INTRODUCTION:
Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage.METHODS:
Plasma profiles were measured before and after exercise in 3 groups subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects.RESULTS:
Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time.CONCLUSIONS:
Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
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Doença de Depósito de Glicogênio Tipo V
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Músculo Esquelético
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Troponina I
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Distrofia Muscular de Duchenne
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Conectina
Tipo de estudo:
Observational_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article