Effect of an oxytocin receptor antagonist (atosiban) on uterine electrical activity.
Am J Obstet Gynecol
; 209(4): 384.e1-7, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23727522
ABSTRACT
OBJECTIVE:
The purpose of this study was to investigate the effect of atosiban (Tractocile; Ferring, Limhamn, Sweden), an oxytocin receptor antagonist, on uterine electrical activity in women with preterm labor and to determine whether this information can assist in the prediction of preterm delivery. STUDYDESIGN:
Uterine electrical activity was recorded prospectively in 21 women with preterm labor before and during treatment with Tractocile and, for purpose of comparison, in 4 pregnant women without uterine contractions to set the baseline of uterine electrical activity in a quiescent uterus. Uterine activity was recorded with a noninvasive, 9-channel recorder with an electromyography amplifier and a 3-dimensional position sensor with an automatic data analyzer. Uterine electrical activity was quantified by an electrical uterine monitor (EUM) and measured in microwatts per second (µW/s).RESULTS:
The overall pre-Tractocile EUM index was 3.43 ± 0.58 µW/s, which was significantly higher than baseline uterine activity in women without preterm contractions (2.3 ± 0.11 µW/s; P = .001). During the administration of Tractocile, the EUM index gradually decreased in a relatively constant rate from 3.43 ± 0.58 µW/s to 2.56 ± 0.88 µW/s after 330 minutes of continuous therapy (P < .001). The peak effect of Tractocile was observed 4 hours after the initiation of treatment and was followed by a relative plateau. Women with a latency of <7 days from treatment to delivery were characterized by a distinct EUM-pattern in response to Tractocile, compared with women with a latency of ≥7 days (P < .001). A similar EUM-pattern after the administration of Tractocile was also observed for women who delivered at <37 weeks of gestation compared with the women who delivered at term.CONCLUSION:
Tractocile reduces uterine electrical activity in women with preterm labor. This information can provide more insight into the effects of tocolytic agents and to aid in the risk stratification of preterm delivery in women with preterm contractions.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Útero
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Vasotocina
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Tocolíticos
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Receptores de Ocitocina
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Nascimento Prematuro
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Trabalho de Parto Prematuro
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article