Chromosomal aberrations suggestive of mutagen-related leukemia after 21 years of "therapeutic" radon exposure.
Cancer Genet Cytogenet
; 48(1): 125-30, 1990 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-2372780
A 68-year-old woman with acute myelomonocytic leukemia, who was treated annually for 21 consecutive years by "therapeutic" low-dose radon gas radiation because of spondyloarthritis, is described. The karyotype of the malignant clone was 45,XX, -17, -18,del(5)(q15q33), +t(17;18)(q11.2q23). In 45% of the metaphases, the modal number was between hyperdiploid to near tetraploid. Double minute chromosomes were demonstrated in 60% of the cells. These chromosomal aberrations are suggestive of mutagen-related leukemia.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Mielomonocítica Aguda
/
Leucemia Induzida por Radiação
/
Aberrações Cromossômicas
/
Radônio
/
Mutagênicos
Tipo de estudo:
Etiology_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article