Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion.

Wang, Guocan; Lunardi, Andrea; Zhang, Jiangwen; Chen, Zhenbang; Ala, Ugo; Webster, Kaitlyn A; Tay, Yvonne; Gonzalez-Billalabeitia, Enrique; Egia, Ainara; Shaffer, David R; Carver, Brett; Liu, Xue-Song; Taulli, Riccardo; Kuo, Winston Patrick; Nardella, Caterina; Signoretti, Sabina; Cordon-Cardo, Carlos; Gerald, William L; Pandolfi, Pier Paolo

Wang, Guocan; Lunardi, Andrea; Zhang, Jiangwen; Chen, Zhenbang; Ala, Ugo; Webster, Kaitlyn A; Tay, Yvonne; Gonzalez-Billalabeitia, Enrique; Egia, Ainara; Shaffer, David R; Carver, Brett; Liu, Xue-Song; Taulli, Riccardo; Kuo, Winston Patrick; Nardella, Caterina; Signoretti, Sabina; Cordon-Cardo, Carlos; Gerald, William L; Pandolfi, Pier Paolo.

Afiliação

Wang G; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Lunardi A; BCMB Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10021.
Zhang J; Cancer Biology and Genetics Program, Sloan-Kettering Institute, 1275 York Avenue, New York, New York 10021, USA.
Chen Z; Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
Ala U; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Webster KA; FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Tay Y; Cancer Biology and Genetics Program, Sloan-Kettering Institute, 1275 York Avenue, New York, New York 10021, USA.
Gonzalez-Billalabeitia E; Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
Egia A; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Shaffer DR; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Carver B; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Liu XS; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Taulli R; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Kuo WP; Cancer Biology and Genetics Program, Sloan-Kettering Institute, 1275 York Avenue, New York, New York 10021, USA.
Nardella C; Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
Signoretti S; Human Oncology and Pathogenesis Program, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
Cordon-Cardo C; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Gerald WL; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Pandolfi PP; Department of Developmental Biology, Harvard School Of Dental Medicine, Boston, MA 02115, USA.

Nat Genet ; 45(7): 739-746, 2013 Jul.

Article em En | MEDLINE | ID: mdl-23727861

Assuntos

Senescência Celular/genética; Proteínas de Ligação a DNA/fisiologia; Genes Supressores de Tumor; Neoplasias da Próstata/patologia; Fatores de Transcrição SOX9/genética; Fatores de Transcrição/fisiologia; Animais; Linhagem Celular Tumoral; Transformação Celular Neoplásica/genética; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Regulação para Baixo/genética; Feminino; Regulação Neoplásica da Expressão Gênica/fisiologia; Genes Supressores de Tumor/fisiologia; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Modelos Biológicos; Invasividade Neoplásica; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; Neoplasias da Próstata/genética; Proto-Oncogene Mas; Fatores de Transcrição SOX9/metabolismo; Fatores de Transcrição SOX9/fisiologia; Transdução de Sinais/genética; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Fatores de Transcrição / Genes Supressores de Tumor / Senescência Celular / Proteínas de Ligação a DNA / Fatores de Transcrição SOX9 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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