[Sterol regulatory element binding protein 1 and its target gene networks].
Yi Chuan
; 35(5): 607-15, 2013 May.
Article
em Zh
| MEDLINE
| ID: mdl-23732667
ABSTRACT
Sterol regulatory element binding protein 1 (SREBP-1) is one of the important nuclear transcription factors. SREBP-1 can maintain lipids dynamic equilibrium by regulating the expression of enzymes required for synthesis of endogenous cholesterol, fatty acids, triglycerides and phospholipids. Anomalies of SREBP-1 and its target genes can cause a series of metabolic diseases such as insulin resistance, type â
¡ diabetes, heart dysfunction, vascular complications and hepatic steatosis. In these years, the development of high-throughput technologies has greatly expanded our knowledge about SREBP-1 target genes and the pattern of transcriptional regulation. Here we reviewed recent research progress of SREBP-1, with a focus on the protein structure, activation process, DNA binding sites and target genes. Most importantly, we showed the transcriptional regulatory networks based on omics datasets, which will contribute to a better understanding of the role of SREBP-1 in lipid metabolism and provide new clues for the treatment of lipid metabolism disorders.
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Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
/
Proteína de Ligação a Elemento Regulador de Esterol 1
/
Redes Reguladoras de Genes
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article