Human papillomavirus types in cases of squamous cell carcinoma of head and neck in Colombia.
Braz J Otorhinolaryngol
; 79(3): 375-81, 2013.
Article
em En, Pt
| MEDLINE
| ID: mdl-23743755
ABSTRACT
UNLABELLED Estimating the type-specific prevalence of human papillomavirus (HPV) in head and neck cancer (HNSCC) is helpful in predicting the impact of HPV immunization. OBJECTIVE:
To estimate the overall prevalence, and gender and age-specific prevalence of HPV in HNSCC.METHOD:
This cross sectional retrospective study was carried out in four pathology laboratories of Medellin, Colombia. HPV testing was performed by GP5+/6+ PCR-based RLB and HPV 16 and 18 type-specific PCR.RESULTS:
175 primary HNSCC cases consecutively diagnosed between 1999 and 2008 with confirmed diagnosis and amplifiable DNA were included. Overall HPV prevalence was 18.9%. HPV was found in 23.9%, 17.5% and 13.3% of the oral cavity, larynx and oropharynx cases respectively. Among HPV positive cases, 82% were HPV 16 and 18% were HPV 18. No other HPV genotypes were identified. Most patients were males. Male patients were younger that their female counterparts, particularly in oral cavity cancer cases.CONCLUSION:
HPV 16 and 18 genotypes were found in nearly 20% of HNSCC cases in Colombian patients. The impact of HPV vaccination for the prevention of HNSCC in this population deserves further evaluation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Neoplasias Orofaríngeas
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Neoplasias Laríngeas
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Infecções por Papillomavirus
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Papillomavirus Humano 16
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Papillomavirus Humano 18
Tipo de estudo:
Observational_studies
/
Prevalence_studies
Limite:
Adult
/
Aged
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Aged80
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Female
/
Humans
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Male
/
Middle aged
País como assunto:
America do sul
/
Colombia
Idioma:
En
/
Pt
Ano de publicação:
2013
Tipo de documento:
Article