Mechanical unfolding of long human telomeric RNA (TERRA).
Chem Commun (Camb)
; 49(57): 6397-9, 2013 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-23748212
ABSTRACT
We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order structures comprised of single parallel G-quadruplex blocks, which unfold at lower forces than their DNA counterparts.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Quadruplex G
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article