Value of SOX10 immunostaining in tumor diagnosis.
Adv Anat Pathol
; 20(4): 275-83, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23752089
ABSTRACT
SOX10 is a transcription factor that is essential for the generation of neural crest cells, their survival, and maintenance of pluripotency. Recent studies have shown that, among tumors, SOX10 is commonly expressed in melanomas, including desmoplastic melanomas, tumors with Schwann cell differentiation, and some salivary gland neoplasms, particularly those with myoepithelial differentiation. Because of its restricted expression, SOX10 has proved to be a useful immunohistochemical marker with a wide range of diagnostic applications in surgical pathology, some of which are briefly reviewed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imuno-Histoquímica
/
Biomarcadores Tumorais
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Fatores de Transcrição SOXE
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Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article