Generating spinal motor neuron diversity: a long quest for neuronal identity.
Cell Mol Life Sci
; 71(5): 813-29, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-23765105
ABSTRACT
Understanding how thousands of different neuronal types are generated in the CNS constitutes a major challenge for developmental neurobiologists and is a prerequisite before considering cell or gene therapies of nervous lesions or pathologies. During embryonic development, spinal motor neurons (MNs) segregate into distinct subpopulations that display specific characteristics and properties including molecular identity, migration pattern, allocation to specific motor columns, and innervation of defined target. Because of the facility to correlate these different characteristics, the diversification of spinal MNs has become the model of choice for studying the molecular and cellular mechanisms underlying the generation of multiple neuronal populations in the developing CNS. Therefore, how spinal motor neuron subpopulations are produced during development has been extensively studied during the last two decades. In this review article, we will provide a comprehensive overview of the genetic and molecular mechanisms that contribute to the diversification of spinal MNs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nervos Espinhais
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Transdução de Sinais
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Diferenciação Celular
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Neurogênese
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Modelos Biológicos
/
Neurônios Motores
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article