Synthesis and antifungal activities of cyclic octa-lipopeptide burkholdine analogues.
Bioorg Med Chem Lett
; 23(14): 4244-7, 2013 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-23769641
ABSTRACT
Synthesis and antifungal activity of cyclic octapeptide derivatives of burkholdines are described. To construct cyclic octapeptides, the combination of Fmoc-SPPS and cyclization with DIC/HOBt in the solution phase was employed. Synthesized peptides were evaluated for antifungal activity with MIC values against Saccharomyces cerevisiae, Aspergillus oryzae, and Candida viswanathii. As a result, the lipid side chain and the stereochemistry of each amino acid of Bk-1097 analogues significantly affected antifungal activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Lipopeptídeos
/
Antifúngicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article