Compartmentalized and systemic control of tissue immunity by commensals.
Nat Immunol
; 14(7): 646-53, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23778791
ABSTRACT
The body is composed of various tissue microenvironments with finely tuned local immunosurveillance systems, many of which are in close apposition with distinct commensal niches. Mammals have formed an evolutionary partnership with the microbiota that is critical for metabolism, tissue development and host defense. Despite our growing understanding of the impact of this host-microbe alliance on immunity in the gastrointestinal tract, the extent to which individual microenvironments are controlled by resident microbiota remains unclear. In this Perspective, we discuss how resident commensals outside the gastrointestinal tract can control unique physiological niches and the potential implications of the dialog between these commensals and the host for the establishment of immune homeostasis, protective responses and tissue pathology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ecossistema
/
Metagenoma
Limite:
Animals
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Female
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article