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Assessment of the combination of doripenem plus a fluoroquinolone against non-susceptible Acinetobacter baumannii isolates from nosocomial pneumonia patients.
Queenan, Anne Marie; Davies, Todd A; He, Wenping; Lynch, Anthony S.
Afiliação
  • Queenan AM; Janssen Research and Development, LLC, Raritan, NJ 08869, USA.
J Chemother ; 25(3): 141-7, 2013 Jun.
Article em En | MEDLINE | ID: mdl-23783138
Carbapenem- and fluoroquinolone-non-susceptible Acinetobacter baumannii were obtained from four nosocomial pneumonia patients who were clinically cured following combination therapy with doripenem/levofloxacin or ciprofloxacin. In vitro synergy of doripenem/levofloxacin or ciprofloxacin was evaluated using time-kill analysis. In vivo synergy was tested using a mouse lethal infection model. In time-kill studies, doripenem and levofloxacin were both bactericidal when tested at Cmax; at ½Cmax, the combination showed synergy up to 8 hours. Ciprofloxacin, alone or combined with doripenem, was not bactericidal. For mouse septicemia, doripenem (100 mg/kg) was ≥90% effective in preventing death in all four isolates. Levofloxacin (200 mg/kg) was 73% effective, and ciprofloxacin (35 mg/kg) was ineffective in preventing death. At lower drug concentrations, increased efficacy was observed for doripenem/levofloxacin, but not for doripenem/ciprofloxacin. Overall, the results suggest that a doripenem/levofloxacin combination may have clinical utility in treating some non-susceptible A. baumannii infections.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Acinetobacter / Ofloxacino / Ciprofloxacina / Carbapenêmicos / Resistência a Múltiplos Medicamentos / Acinetobacter baumannii / Pneumonia Associada à Ventilação Mecânica / Levofloxacino Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Acinetobacter / Ofloxacino / Ciprofloxacina / Carbapenêmicos / Resistência a Múltiplos Medicamentos / Acinetobacter baumannii / Pneumonia Associada à Ventilação Mecânica / Levofloxacino Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Ano de publicação: 2013 Tipo de documento: Article