Is JmjC oxygenase catalysis limited to demethylation?
Angew Chem Int Ed Engl
; 52(30): 7709-13, 2013 Jul 22.
Article
em En
| MEDLINE
| ID: mdl-23788451
ABSTRACT
Jobs on the side Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone N(ε)-methyllysine demethylases are capable of catalyzing the de-N-alkylation of groups other than N-methyl and can catalyze reactions that form stable hydroxylated products. The differences in binding preferences in this set of enzymes may be helpful in the design of selective inhibitors.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Histona Desmetilases com o Domínio Jumonji
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article