The role of epigenetics in malignant pleural mesothelioma.
Lung Cancer
; 81(3): 311-318, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23790315
ABSTRACT
Malignant pleural mesothelioma (MPM) is an almost invariably fatal cancer of the pleura due to asbestos exposure. Increasing evidence indicates that unresponsiveness to chemotherapy is due to epigenetic errors leading to inadequate gene expression in tumor cells. The availability of compounds that modulate epigenetic modifications, such as histone acetylation or DNA methylation, offers new prospects for treatment of MPM. Here, we review latest findings on epigenetics in mesothelioma and present novel strategies for promising epigenetic therapies.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pleurais
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Epigênese Genética
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Neoplasias Pulmonares
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Mesotelioma
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article