Rice varietal differences in bioactive bran components for inhibition of colorectal cancer cell growth.
Food Chem
; 141(2): 1545-52, 2013 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-23790950
ABSTRACT
Rice bran chemical profiles differ across rice varieties and have not yet been analysed for differential chemopreventive bioactivity. A diverse panel of seven rice bran varieties was analysed for growth inhibition of human colorectal cancer (CRC) cells. Inhibition varied from 0% to 99%, depending on the variety of bran used. Across varieties, total lipid content ranged 5-16%, individual fatty acids had 1.4- to 1.9-fold differences, vitamin E isoforms (α-, γ-, δ-tocotrienols, and tocopherols) showed 1.3- to 15.2-fold differences, and differences in γ-oryzanol and total phenolics ranged between 100-275ng/mg and 57-146ngGAE/mg, respectively. Spearman correlation analysis was used to identify bioactive compounds implicated in CRC cell growth inhibitory activity. Total phenolics and γ-tocotrienol were positively correlated with reduced CRC cell growth (p<0.05). Stoichiometric variation in rice bran components and differential effects on CRC viability merit further evaluation elucidate their role in dietary CRC chemoprevention.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oryza
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Fibras na Dieta
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Extratos Vegetais
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Neoplasias Colorretais
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Proliferação de Células
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Inibidores do Crescimento
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article