Vialinin A is a ubiquitin-specific peptidase inhibitor.
Bioorg Med Chem Lett
; 23(15): 4328-31, 2013 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-23791076
ABSTRACT
Vialinin A, a small compound isolated from the Chinese mushroom Thelephora vialis, exhibits more effective anti-inflammatory activity than the widely used immunosuppressive drug tacrolimus (FK506). Here, we show that ubiquitin-specific peptidase 5/isopeptidase T (USP5/IsoT) is a target molecule of vialinin A, identified by using a beads-probe method. Vialinin A inhibited the peptidase activity of USP5/IsoT and also inhibited the enzymatic activities of USP4 among deubiquitinating enzymes tested. Although USPs are a member of thiol protease family, vialinin A exhibited no inhibitions for other thiol proteases, such as calpain and cathepsin.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
/
Inibidores de Proteases
/
Compostos de Terfenil
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article