Bromodomain proteins in HIV infection.
Viruses
; 5(6): 1571-86, 2013 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-23793227
ABSTRACT
Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
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Replicação Viral
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Proteínas Nucleares
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Regulação Viral da Expressão Gênica
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HIV
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Integração Viral
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Interações Hospedeiro-Patógeno
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article