Clinical outcomes after zotarolimus and everolimus drug eluting stent implantation in coronary artery bifurcation lesions: insights from the RESOLUTE All Comers Trial.
Heart
; 99(17): 1267-74, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23800571
ABSTRACT
OBJECTIVE:
We investigated clinical outcomes after treatment of coronary bifurcation lesions with second generation drug eluting stents (DES).DESIGN:
Post hoc analysis of a randomised, multicentre, non-inferiority trial.SETTING:
Multicentre study. PATIENTS All comers study with minimal exclusion criteria.INTERVENTIONS:
Patients were treated with either zotarolimus or everolimus eluting stents. The patient population was divided according to treatment of bifurcation or non-bifurcation lesions and clinical outcomes were compared between groups. MAIN OUTCOMESMEASURES:
Clinical outcomes within 2-year follow-up.RESULTS:
A total of 2265 patients were included in the present analysis. Two-year follow-up data were available in 2223 patients 1838 patients in the non-bifurcation group and 385 patients in the bifurcation group. At 2-year follow-up the bifurcation and the non-bifurcation lesion groups showed no significant differences in terms of cardiac death (2.3 vs 2.1, p=0.273), target lesion failure (9.7% vs 13.8%, p=0.255), major adverse cardiac events (11.5% vs 15.1%, p=0.305), target lesion revascularisation (4.7% vs 6.0%, p=0.569), and definite or probable stent thrombosis (1.6% vs 1.8%, p=0.419).CONCLUSIONS:
The use of second generation DES for the treatment of coronary bifurcation lesions was associated with similar long term mortality and clinical outcomes compared with non-bifurcation lesions.
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Base de dados:
MEDLINE
Assunto principal:
Sirolimo
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Estenose Coronária
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Stents Farmacológicos
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Intervenção Coronária Percutânea
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Imunossupressores
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article