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Successful treatment of a patient with multicentric Castleman's disease who presented with thrombocytopenia, ascites, renal failure and myelofibrosis using tocilizumab, an anti-interleukin-6 receptor antibody.
Kawabata, Hiroshi; Kotani, Shin-ichi; Matsumura, Yumi; Kondo, Tadakazu; Katsurada, Tatsuya; Haga, Hironori; Kadowaki, Norimitsu; Takaori-Kondo, Akifumi.
Afiliação
  • Kawabata H; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan. hkawabat@kuhp.kyoto-u.ac.jp
Intern Med ; 52(13): 1503-7, 2013.
Article em En | MEDLINE | ID: mdl-23812199
We herein describe an unusual case of multicentric Castleman's disease accompanied by thrombocytopenia, ascites, renal failure and myelofibrosis in a Japanese woman. The patient was initially diagnosed as having myelodysplastic syndrome with myelofibrosis. The general condition of the patient deteriorated rapidly; however, treatment with tocilizumab, an anti-interleukin-6 receptor antibody, together with corticosteroids dramatically improved her symptoms. The clinical features of this case were similar to those of three cases previously reported by Takai et al. (Rinsho Ketsueki, 2010, 51:320-5), which were determined to be thrombocytopenia, anasarca, fever, reticulin myelofibrosis and organomegaly (TAFRO) syndrome, a possibly distinct clinical entity.
Assuntos
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Base de dados: MEDLINE Assunto principal: Ascite / Trombocitopenia / Hiperplasia do Linfonodo Gigante / Receptores de Interleucina-6 / Insuficiência Renal / Mielofibrose Primária / Anticorpos Monoclonais Humanizados Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Ascite / Trombocitopenia / Hiperplasia do Linfonodo Gigante / Receptores de Interleucina-6 / Insuficiência Renal / Mielofibrose Primária / Anticorpos Monoclonais Humanizados Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article