Functional genomics approaches to understand cytomegalovirus replication, latency and pathogenesis.
Curr Opin Virol
; 3(4): 408-15, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23816389
ABSTRACT
Cytomegalovirus (CMV) is a species-specific herpesvirus that is ubiquitous in the population and has the potential to cause significant disease in immunocompromised individuals as well as in congenitally infected infants. CMV establishes latency in cells of the myeloid lineage following primary infection. High-throughput functional genomics approaches have provided insight into the mechanisms of CMV replication, but although CMV latency cell models have been useful in elucidating the mechanisms of viral latency and reactivation, omics approaches have proven challenging in these cell systems. This review will summarize the current state of knowledge concerning the use of functional genomics technologies to understand mechanisms of CMV replication, latency and pathogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Latência Viral
/
Infecções por Citomegalovirus
/
Genômica
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Citomegalovirus
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article