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Effect of prednisone on the pharmacokinetics of the integrase inhibitor dolutegravir.
Song, Ivy H; Borland, Julie; Chen, Shuguang; Savina, Paul; Peppercorn, Amanda F; Piscitelli, Stephen.
Afiliação
  • Song IH; GlaxoSmithKline, Research Triangle Park, North Carolina, USA.
Antimicrob Agents Chemother ; 57(9): 4394-7, 2013 Sep.
Article em En | MEDLINE | ID: mdl-23817375
ABSTRACT
Prednisone, a corticosteroid frequently used to treat common AIDS-related illnesses and comorbidities, has been shown to induce drug metabolism. This study was performed to determine whether prednisone coadministration affected the pharmacokinetics of dolutegravir (DTG). In this open-label, repeat-dose study, 12 healthy subjects were administered DTG at 50 mg daily alone for 5 days and then with concomitant prednisone for 10 days (prednisone at 60 mg daily for 5 days, followed by a 5-day taper). Serial blood sampling and safety assessments were performed during the trial. Pharmacokinetic parameters were determined using noncompartmental methods and geometric least-square mean ratios, and 90% confidence intervals were generated. Coadministration of DTG and 5-day high-dose prednisone with a 5-day taper had a modest effect on DTG exposure. The area under the DTG plasma concentration-time curve, maximum observed DTG concentration, and 24-hour postdose DTG concentration were increased by 11%, 6%, and 17%, respectively, on day 10 of the combination. Similar results were observed after 5 days of DTG and prednisone. Dolutegravir and prednisone coadministration was well tolerated. The changes in plasma exposures of DTG in healthy individuals as a result of prednisone dosing were not clinically significant. No dose adjustment is required for DTG coadministered with prednisone. (This study has been registered at ClinicalTrials.gov under registration no. NCT01425099.).
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Prednisona / Inibidores de Integrase de HIV / Compostos Heterocíclicos com 3 Anéis Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Prednisona / Inibidores de Integrase de HIV / Compostos Heterocíclicos com 3 Anéis Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article