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Magnetic resonance T1 relaxation time of venous thrombus is determined by iron processing and predicts susceptibility to lysis.
Saha, Prakash; Andia, Marcelo E; Modarai, Bijan; Blume, Ulrike; Humphries, Julia; Patel, Ashish S; Phinikaridou, Alkystis; Evans, Colin E; Mattock, Katherine; Grover, Steven P; Ahmad, Anwar; Lyons, Oliver T; Attia, Rizwan Q; Renné, Thomas; Premaratne, Sobath; Wiethoff, Andrea J; Botnar, René M; Schaeffter, Tobias; Waltham, Matthew; Smith, Alberto.
Afiliação
  • Saha P; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Andia ME; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Modarai B; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Blume U; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Humphries J; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Patel AS; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Phinikaridou A; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Evans CE; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Mattock K; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Grover SP; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Ahmad A; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Lyons OT; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Attia RQ; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Renné T; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Premaratne S; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Wiethoff AJ; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Botnar RM; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Schaeffter T; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Waltham M; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
  • Smith A; Academic Department of Surgery, Cardiovascular Division, Kings College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at Kings Health Partners, St Thomas' Hospital, London, UK (P.S., B.M., J.H., A.S.P., C.E.E., K.M., S.P.G., A.A., O.T.L., R.Q.A., S.P., M.W., A.S.); D
Circulation ; 128(7): 729-736, 2013 Aug 13.
Article em En | MEDLINE | ID: mdl-23820077
ABSTRACT

BACKGROUND:

The magnetic resonance longitudinal relaxation time (T1) changes with thrombus age in humans. In this study, we investigate the possible mechanisms that give rise to the T1 signal in venous thrombi and whether changes in T1 relaxation time are informative of the susceptibility to lysis. METHODS AND

RESULTS:

Venous thrombosis was induced in the vena cava of BALB/C mice, and temporal changes in T1 relaxation time correlated with thrombus composition. The mean T1 relaxation time of thrombus was shortest at 7 days following thrombus induction and returned to that of blood as the thrombus resolved. T1 relaxation time was related to thrombus methemoglobin formation and further processing. Studies in inducible nitric oxide synthase (iNOS(-/-))-deficient mice revealed that inducible nitric oxide synthase mediates oxidation of erythrocyte lysis-derived iron to paramagnetic Fe3+, which causes thrombus T1 relaxation time shortening. Studies using chemokine receptor-2-deficient mice (Ccr2(-/-)) revealed that the return of the T1 signal to that of blood is regulated by removal of Fe3+ by macrophages that accumulate in the thrombus during its resolution. Quantification of T1 relaxation time was a good predictor of successful thrombolysis with a cutoff point of <747 ms having a sensitivity and specificity to predict successful lysis of 83% and 94%, respectively.

CONCLUSIONS:

The source of the T1 signal in the thrombus results from the oxidation of iron (released from the lysis of trapped erythrocytes in the thrombus) to its paramagnetic Fe3+ form. Quantification of T1 relaxation time appears to be a good predictor of the success of thrombolysis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Trombose Venosa / Fibrinólise / Ferro Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Trombose Venosa / Fibrinólise / Ferro Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article