Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group.
Org Biomol Chem
; 11(30): 4921-4, 2013 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-23820826
ABSTRACT
A removable protecting group has been identified that allows the products of widely-used cross dehydrogenative couplings to be synthetically elaborated. The method can be used with enantiopure amines with no loss of enantiomeric excess. The methodology is exemplified by a new synthesis of enantiopure praziquantel, the drug used in the treatment of millions of people suffering from the neglected tropical disease, schistosomiasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Praziquantel
/
Aminas
/
Anti-Helmínticos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article