Transcription Factor Activating Protein-2ß (TFAP-2ß) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples.
Eur Child Adolesc Psychiatry
; 23(4): 207-17, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-23824473
ABSTRACT
The Transcription Factor Activating Protein-2ß (TFAP-2ß) gene has been shown to influence monoaminergic neurotransmission, and several genes important for monoaminergic function have binding sites for TFAP-2ß. Familial studies of attention deficit hyperactivity disorder (ADHD) suggest a hereditary-determined subtype of ADHD with comorbid depression. We examined a functional variation of the TFAP-2ß gene in the context of co-occurring symptoms of ADHD and depression in two independent population-based samples of adolescents (Group A, n = 175 and Group B, n = 1,506) from Sweden. Results indicated 6.1 to 7.8% of adolescents screened positively for ADHD and depression symptoms. Symptoms of depression were more common among girls who screened positively for ADHD and did not carry the nine-repeat allele of the TFAP-2ß intron 1 Variable Number Tandem Repeat (VNTR) polymorphism. The presence of the nine-repeat variant of the TFAP-2ß intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Transtorno do Deficit de Atenção com Hiperatividade
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Depressão
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Fator de Transcrição AP-2
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adolescent
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Female
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Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article