Significant pathways response to osmotic stimuli in the intervertebral disc.
Eur Rev Med Pharmacol Sci
; 17(12): 1620-5, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23832728
ABSTRACT
BACKGROUND:
The intervertebral disc (IVD) is a special tissue localized in the middle of vertebrae and it often experiences osmotic environment to accommodate applied mechanical forces.AIM:
Here we aim to confirm significant pathways associated with IVD osmotic regulation. MATERIALS ANDMETHODS:
Two different pathway analyses which are named component-based approach and protein-protein interaction (PPI)-based approach are used to identify the significant pathways from the related databases.RESULTS:
The results showed that neuroactive ligand-receptor interaction pathway was specifically identified based on traditional significant pathway analysis. New significant pathway analysis indicated that ErbB signaling pathway, nucleotide excision repair, progesterone-mediated oocyte maturation pathway, and alpha-Linolenic acid metabolism pathway, etc. were all associated with osmotic regulation. Importantly, progesterone-mediated oocyte maturation pathway was only significant in the hyper-osmotic dataset, however, alpha-Linolenic acid metabolism pathway in the hypo-osmotic dataset.CONCLUSIONS:
Our results suggest that IVD accommodation mechanism is important in response to osmotic stimuli.
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Base de dados:
MEDLINE
Assunto principal:
Osmose
/
Disco Intervertebral
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article