[The research progress of Aurora-B kinase and its inhibitors].
Yao Xue Xue Bao
; 48(4): 457-65, 2013 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-23833930
ABSTRACT
Aurora-B as an important kinase to adjust the cell normal mitosis is a potent target for cancer treatment. Aurora-B is overexpressed in a broad range of tumor and tumor cells are more sensitive while Aurora-B is inhibited. Due to the key role of the Aurora-B in cell mitosis, the development of its inhibitors is becoming more and more important. Several small molecules inhibit with a similar efficacy both Aurora-A and Aurora-B, however, in most cases the effects resemble Aurora-B disruption by genetic methods, indicating that Aurora-B represents an effective therapeutic target. There were several Aurora-B kinase inhibitors which had entered the clinics and displayed good antitumor activity. In this review, we will outline the functions of Aurora kinase B in normal cell division and in malignancy. We will focus on recent preclinical and clinical studies that have explored the mechanism of action and clinical effect of Aurora-B inhibitors in cancer treatment.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteínas Quinases
/
Aurora Quinase B
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article