Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⺠T cells.
Eur J Immunol
; 43(10): 2730-40, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23839924
ABSTRACT
Type I interferons (IFNs) have the dual ability to promote the development of the immune response and exert an anti-inflammatory activity. We analyzed the integrated effect of IFN-α, TCR signal strength, and CD28 costimulation on human CD4⺠T-cell differentiation into cell subsets producing the anti- and proinflammatory cytokines IL-10 and IFN-γ. We show that IFN-α boosted TCR-induced IL-10 expression in activated peripheral CD45RAâºCD4⺠T cells and in whole blood cultures. The functional cooperation between TCR and IFN-α efficiently occurred at low engagement of receptors. Moreover, IFN-α rapidly cooperated with anti-CD3 stimulation alone. IFN-α, but not IL-10, drove the early development of type I regulatory T cells that were mostly IL-10⺠Foxp3â» IFN-γ⻠and favored IL-10 expression in a fraction of Foxp3⺠T cells. Our data support a model in which IFN-α costimulates TCR toward the production of IL-10 whose level can be amplified via an autocrine feedback loop.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
/
Interferon-alfa
/
Linfócitos T Reguladores
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article