High serum leptin levels in infancy can potentially predict obesity in childhood, especially in formula-fed infants.
Acta Paediatr
; 102(10): e455-9, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23844562
ABSTRACT
AIM:
To investigate serum leptin levels in breast-fed and formula-fed infants in infancy and their possible relationship to body mass index (BMI) in childhood.METHODS:
We enrolled 237 healthy term infants between September 2000 and April 2004 and tested their serum leptin levels, took anthropometric measurements and calculated BMI. A follow-up study was carried out to evaluate the BMI of 89 of these infants in childhood, in relation to their serum leptin levels in infancy, at a median (interquartile range) age of 8.8 years (7.8-10.2). The statistical significance of this multivariate analysis was set at p < 0.05.RESULTS:
Breast-fed infants had significantly higher serum leptin levels than formula-fed ones (p < 0.05). Children who were formula-fed in infancy had a significantly higher BMI, at follow-up, than those who were breast-fed (p < 0.001). Furthermore, we identified a leptin cut-off value of 2.7 ng/mL, below which infants had a higher BMI in childhood.CONCLUSION:
A higher leptin level in infancy may be inversely associated with BMI in childhood, suggesting that this hormone in infancy is a potential predictor of obesity in later life. Further investigation is required to be conclusive and to confirm our empirical evidence.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Aleitamento Materno
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Leptina
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Fórmulas Infantis
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Obesidade Infantil
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article