Adiponectin in inflammatory and immune-mediated diseases.
Cytokine
; 64(1): 1-10, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23850004
ABSTRACT
Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities, with inflammation playing an important role in downregulating APN production. In contrast to obesity and metabolic disease, elevated systemic and local levels of APN are present in patients with inflammatory and immune-mediated diseases, including autoimmune and pulmonary conditions, heart and kidney failure, viral hepatitis, organ transplantation and perhaps critical illness. A positive association between inflammation and APN is usually reported in inflammatory/immune pathologies, in contrast with the negative correlation typical of metabolic disease. This review discusses the role of APN in modulation of inflammation and immunity and the potential mechanisms leading to increased levels of APN in inflammatory/immune diseases, including modification of adipose tissue physiology; relative contribution of different tissues and adipose depots; hormonal, pharmacological, nutritional and life style factors; the potential contribution of the microbiota as well as the role of altered APN clearance and release from T-cadherin-associated tissue reservoirs. Potential reasons for some of the apparently contradictory findings on the role of APN as a modulator of immunity and inflammation are also discussed, including a comparison of types of recombinant APN used for in vitro studies and strain-dependent differences in the phenotype of APN KO mice.
Palavras-chave
APN; Adipokines; Adipose tissue; BMI; COPD; CVD; Disease; GVHD; Immunity; Inflammation; LPS; MW; PPAR; TLR; adiponectin; body mass index; cardiovascular disease; chronic obstructive pulmonary disease; graft-versus-host disease; lipopolysaccharide; molecular weight; peroxisome proliferator-activated receptor; toll-like receptor
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adiponectina
/
Doenças do Sistema Imunitário
/
Inflamação
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article