[Molecular mechanisms of leupaxin involved in prostate carcinoma metastasis].
Zhonghua Nan Ke Xue
; 19(6): 555-8, 2013 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-23862238
ABSTRACT
Leupaxin (LPXN) is a new member of the Paxillin superfamily, mainly located in focal adhesion plaques, involved in the transduction of multiple signaling pathways, and regulating the proliferation, adhesion and migration of tumor cells. In prostate cancer cells, LPXN is not only involved in the integrin signaling transduction pathway, regulating the proliferation, adhesion and migration of prostate cancer cells, but is also a new androgen receptor (AR) coactivator, regulating the transcription of nuclear AR effect genes, participating in AR signal transduction, and regulating the differentiation and invasion of prostate cancer cells. This review focuses on the molecular structure, special roles and molecular mechanisms of LPXN involved in prostatic carcinoma metastasis.
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Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Neoplasias da Próstata
/
Moléculas de Adesão Celular
Limite:
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article