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[Neutrophils and hyaluronians in carcinogenesis]. / Neutrofile i hialuroniany w chorobach nowotworowych.
Pol Merkur Lekarski ; 34(204): 313-5, 2013 Jun.
Article em Pl | MEDLINE | ID: mdl-23882925
ABSTRACT
Inflammatory processes involving polymorphonuclear leukocytes (PMNL) play an important role in cancer. PMNL can affect the formation and growth of the tumor. Cancer cells produce significant amounts of hyaluronans (HA), which pass into the extracellular space and are responsible for the inhibition of PMNL function through TLR4 receptor, and increase in the production of IL 10 the immunosuppressive cytokine as well as the other proinflammatory cytokines. HA supported the metastasis of cancer cells by binding to the CD44 receptor on endothelial cells. Increased PMNL--Lymphocyte ratio as a negative prognostic factor indicates also the important not defined role of PMNL in carcinogenesis.
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Base de dados: MEDLINE Assunto principal: Interleucina-10 / Ácido Hialurônico / Neoplasias / Neutrófilos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: Pl Ano de publicação: 2013 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Interleucina-10 / Ácido Hialurônico / Neoplasias / Neutrófilos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: Pl Ano de publicação: 2013 Tipo de documento: Article