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Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview.
Manola, Kalliopi N.
Afiliação
  • Manola KN; Laboratory of Health Physics & Enviromental Health, Department of Cytogenetics, National Centre for Scientific Research (NCSR) "Demokritos", Aghia Paraskevi, Athens, Greece.
Br J Haematol ; 163(1): 24-39, 2013 Oct.
Article em En | MEDLINE | ID: mdl-23888868
Acute leukaemia of ambiguous lineage (ALAL) is a rare complex entity with heterogeneous clinical, immunophenotypic, cytogenetic and molecular genetic features and adverse outcome. According to World Health Organization 2008 classification, ALAL encompasses those leukaemias that show no clear evidence of differentiation along a single lineage. The rarity of ALAL and the lack of uniform diagnostic criteria have made it difficult to establish its cytogenetic features, although cytogenetic analysis reveals clonal chromosomal abnormalities in 59-91% of patients. This article focuses on the significance of cytogenetic analysis in ALAL supporting the importance of cytogenetic analysis in the pathogenesis, diagnosis, prognosis, follow up and treatment selection of ALAL. It reviews in detail the types of chromosomal aberrations, their molecular background, their correlation with immunophenotype and age distribution and their prognostic relevance. It also summarizes some novel chromosome aberrations that have been observed only once. Furthermore, it highlights the ongoing and future research on ALAL in the field of cytogenetics.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Aguda Bifenotípica / Aberrações Cromossômicas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Aguda Bifenotípica / Aberrações Cromossômicas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article