Perspective on the discovery and scientific impact of p38 MAP kinase.
J Biomol Screen
; 18(10): 1156-63, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23896688
ABSTRACT
It has now been almost 20 years since the discovery of p38 MAP kinase and its role in inflammatory cytokine synthesis through reverse pharmacology and its subsequent exploration as a potential target for autoimmune and other diseases. At the time of its discovery, the use of cell-based phenotypic screens to identify new molecular targets was at its infancy, and while p38 MAP kinase was not the first target to be identified this way, it provides a useful model for reviewing the pros and cons of this approach and the subsequent impact it can have on discovering new medicines.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases p38 Ativadas por Mitógeno
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article