Aryl hydrocarbon receptor control of adaptive immunity.
Pharmacol Rev
; 65(4): 1148-61, 2013.
Article
em En
| MEDLINE
| ID: mdl-23908379
ABSTRACT
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that belongs to the family of basic helix-loop-helix transcription factors. Although the AhR was initially recognized as the receptor mediating the pathologic effects of dioxins and other pollutants, the activation of AhR by endogenous and environmental factors has important physiologic effects, including the regulation of the immune response. Thus, the AhR provides a molecular pathway through which environmental factors modulate the immune response in health and disease. In this review, we discuss the role of AhR in the regulation of the immune response, the source and chemical nature of AhR ligands, factors controlling production and degradation of AhR ligands, and the potential to target the AhR for therapeutic immunomodulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Hidrocarboneto Arílico
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article