Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus.
Neuroscience
; 250: 658-63, 2013 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-23911810
Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that requires coactivation of GABA(A)Rs and muscarinic acetylcholine receptors (mAChRs), and endocytosis of AMPARs. Thus, we disclose that a patterned high-frequency stimulation triggers GABAAR and mAChR-dependent LTD in the hippocampus.
Palavras-chave
(RS)-α-methyl-4-carboxyphenylglycine; ACSF; ACh; Atrp; BIC; D-AP5; DMSO; GABA(A) receptors; HFS; IBI; LFS; LTD; LTP; MCPG; N-methyl-d-aspartic acid receptor; NMDAR; PHS; PTX; Scopo; Sti; TBS; acetylcholine; artificial cerebrospinal fluid; atropine; bicuculline; d-(−)-2-amino-5-phosphonopentanoic acid; dimethyl sulfoxide; fEPSPs; field excitatory postsynaptic potentials; high-frequency stimulation; hippocampal CA1; inter-burst interval; long-term depression; long-term potentiation; low-frequency stimulation; mACh receptors; mAChR; mGluR; metabotropic glutamate receptor; muscarinic acetylcholine receptor; patterned high-frequency stimulation; picrotoxin; scopolamine; stimulation; theta burst stimulation
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Colinérgicos
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Receptores de GABA-A
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Hipocampo
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article