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Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus.
Zhu, Y-Y; Jing, L; Duan, T-T; Yuan, Q; Cao, J; Zhou, Q-X; Xu, L.
Afiliação
  • Zhu YY; Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
Neuroscience ; 250: 658-63, 2013 Oct 10.
Article em En | MEDLINE | ID: mdl-23911810
Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that requires coactivation of GABA(A)Rs and muscarinic acetylcholine receptors (mAChRs), and endocytosis of AMPARs. Thus, we disclose that a patterned high-frequency stimulation triggers GABAAR and mAChR-dependent LTD in the hippocampus.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Colinérgicos / Receptores de GABA-A / Hipocampo / Plasticidade Neuronal Limite: Animals Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Colinérgicos / Receptores de GABA-A / Hipocampo / Plasticidade Neuronal Limite: Animals Idioma: En Ano de publicação: 2013 Tipo de documento: Article