STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury.
EMBO Rep
; 14(10): 931-7, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23928811
ABSTRACT
If and how neurons remodel their connections after CNS injury critically influences recovery of function. Here, we investigate the role of the growth-initiating transcription factor STAT3 during remodelling of the injured corticospinal tract (CST). Endogenous STAT3 expression in lesioned cortical projection neurons is transient but can be sustained by viral gene transfer. Sustained activation of STAT3 enhances remodelling of lesioned CST fibres and induces de novo formation of collaterals from unlesioned CST fibres. In a unilateral pyramidotomy paradigm, this recruitment of unlesioned fibres leads to the formation of midline crossing circuits that establish ipsilateral forelimb activation and functional recovery.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tratos Piramidais
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Traumatismos da Medula Espinal
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Fator de Transcrição STAT3
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Regeneração Nervosa
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article