Nonsmall cell lung cancer therapy: insight into multitargeted small-molecule growth factor receptor inhibitors.
Biomed Res Int
; 2013: 964743, 2013.
Article
em En
| MEDLINE
| ID: mdl-23936861
ABSTRACT
To date, lung cancer is the leading cause of cancer-related death worldwide, among which nonsmall cell lung cancer (NSCLC) comprises about 85%. Taking into account the side effects of surgery, radiation, platinum-based doublet chemotherapy, and the growth self-sufficiency characteristic of cancer cells, drugs have been discovered toward growth factor receptor (GFR) to treat NSCLC. As expected, these drugs provide a greater benefit. To increase the efficacy of such growth factor receptor tyrosine kinase inhibitors (RTKIs), coinhibition of GFR signaling pathways and combination of inhibitors along with radiation or chemotherapy have drew intense insight. Although clinical trials about single-agent RTKIs or their combination strategies suggest their increase potency against cancer, they are not beyond adverse effects, and sometimes the effects are more deadly than chemotherapy. Nevertheless the hope for RTKIs may be proved true by further researches and digging deep into cancer therapeutics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Fatores de Crescimento
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Carcinoma Pulmonar de Células não Pequenas
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Inibidores de Proteínas Quinases
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Terapia de Alvo Molecular
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Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article