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The effect of a first-generation H1-antihistamine on postural control: a preliminary study in healthy volunteers.
Chihara, Yasuhiro; Sato, Ayako; Ohtani, Michiteru; Fujimoto, Chisato; Hayashi, Takahiro; Nishijima, Hironobu; Yagi, Masato; Iwasaki, Shinichi.
Afiliação
  • Chihara Y; National Institute of Sensory Organs, National Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 1528902, Japan, y-chihara@umin.ac.jp.
Exp Brain Res ; 231(3): 257-66, 2013 Nov.
Article em En | MEDLINE | ID: mdl-23955106
ABSTRACT
First-generation H1-antihistamines are known to cause fatigue and drowsiness, due to their poor receptor selectivity and their high penetration rate of the blood-brain barrier. However, little is known about the effects of first-generation H1-antihistamines on postural stability. The purpose of this study was to evaluate the effects of d-chlorpheniramine on postural stability using posturography with and without foam rubber. A double-blind study with three parallel groups was conducted. Twenty-seven healthy young volunteers (mean age 21.9 years) were recruited and orally administered d-chlorpheniramine, 2 or 4 mg, or placebo. Postural sway was measured every hour up to 8 h after administration. Two-legged stance tasks were performed by each subject in four conditions eyes open or eyes closed and with or without foam rubber. Inter-group comparisons showed that the group receiving 4-mg d-chlorpheniramine showed significantly larger sway in the eyes open with foam rubber condition (visual and vestibular information available, somatosensory information reduced). Inter-subject analysis in the 4-mg d-chlorpheniramine group showed that the effect of d-chlorpheniramine on postural control was variable. Our results suggest that among the three main sensory systems responsible for postural control (visual, vestibular, and somatosensory), d-chlorpheniramine may have a larger effect on the visual and/or vestibular systems in susceptible individuals.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Clorfeniramina / Equilíbrio Postural / Antagonistas dos Receptores Histamínicos H1 Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Clorfeniramina / Equilíbrio Postural / Antagonistas dos Receptores Histamínicos H1 Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article