Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice.
Am J Orthod Dentofacial Orthop
; 144(3): 368-80, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23992809
ABSTRACT
INTRODUCTION:
In this study, mechanical stress in the form of tooth movement was applied to osteoprotegerin-deficient knockout mice, which served as an animal model for juvenile Paget's disease. To compare and evaluate bone turnover and response of the surrounding bony tissue, we administered reveromycin A. We also investigated the ability of reveromycin A to control osteoclastic activity in juvenile Paget's disease.METHODS:
Eight-week-old male osteoprotegerin-deficient knockout and wild-type mice were injected with reveromycin A (15 mg/kg of body weight) intraperitoneally twice daily. An elastic module was inserted interproximally between the maxillary left first and second molars.RESULTS:
Administration of reveromycin A to osteoprotegerin-deficient knockout mice reduced tooth movement distances, increased bone volumes at the interradicular septum, decreased osteoclast counts, and reduced serum alkaline phosphatase and tartrate resistant acid phosphatase. Reveromycin A administration also caused a temporal shift in peak Runx2 staining in osteoprotegerin-deficient knockout mice so that the overall staining time course was similar to that observed for wild-type mice.CONCLUSIONS:
Reveromycin A administration in osteoprotegerin-deficient knockout mice inhibited bone resorption and normalized bone formation. As a result, normal bone turnover was obtained.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Compostos de Espiro
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Técnicas de Movimentação Dentária
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Perda do Osso Alveolar
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Remodelação Óssea
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Antimitóticos
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Osteoprotegerina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article