Intravenous immunoglobulin-mediated immunosuppression and the development of an IVIG substitute.
Clin Exp Med
; 14(4): 361-73, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-23996469
ABSTRACT
Immunoglobulins are glycoproteins produced by the cells of the immune system. Their primary function is to protect the body from pathogenic infection. Moreover, a concentrated polyclonal mixture of immunoglobulin G (IgG), the so-called intravenous IgG (IVIG), has been used to treat various chronic and systemic disorders of the immune system. Studies on the effects of IVIG in autoimmune disease models have revealed that IgG Fc fragments confer protection against various autoimmune diseases. The identification of this IgG Fc immunomodulatory component is important for the development of IVIG substitutes. The focus of this review is to introduce one of the Fc regulatory entities and to provide a summary of the current knowledge of the putative general mechanisms underlying IVIG activity in vivo on the basis of these Fc fragments. We also address the recent insights into several approaches for the development of IVIG substitutes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos Fc das Imunoglobulinas
/
Terapia de Imunossupressão
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Imunoglobulinas Intravenosas
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Imunossupressores
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article