γ-Substituted butanolides from cyclopropane hemimalonates: an expedient synthesis of natural (R)-dodecan-4-olide.
Org Lett
; 15(18): 4838-41, 2013 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-24007510
ABSTRACT
Exploration into the reactivity of donor-acceptor cyclopropane hemimalonates has led to the facile synthesis of γ-substituted butanolides. Under microwave irradiation, cyclopropane hemimalonates undergo rapid conversion to butanolides in the presence of inorganic salts with an unprecedented retention of stereochemistry. This unique process has been applied to the total synthesis of the naturally occurring (R)-dodecan-4-olide.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
4-Butirolactona
/
Ciclopropanos
/
Lactonas
/
Malonatos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article