Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents.
Bioorg Med Chem
; 21(21): 6600-7, 2013 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-24012457
Palavras-chave
Antitrypanosomal agents; Benzothiazoles; Bnz; Chagas disease; HAT; IC(50); NTR; Nfx; Nitrotriazoles; Piperazines; SARs; SI; Structureactivity relationships; T. brucei; T. brucei NTR; T. cruzi; TDR; TbNTR; Tropical diseases research (http://www.who.int/tdr/en/); Trypanosoma brucei; Trypanosoma cruzi; benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide); concentration for 50% growth inhibition; human African trypanosomiasis; nifurtimox (4-(5-nitrofurfurylindenamino)-3-methylthio-morpholine-1,1-dioxide); selectivity index; type I nitroreductase
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Triazóis
/
Tripanossomicidas
/
Benzotiazóis
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article