Murine models of Candida gastrointestinal colonization and dissemination.
Eukaryot Cell
; 12(11): 1416-22, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24036344
ABSTRACT
Ninety-five percent of infectious agents enter through exposed mucosal surfaces, such as the respiratory and gastrointestinal (GI) tracts. The human GI tract is colonized with trillions of commensal microbes, including numerous Candida spp. Some commensal microbes in the GI tract can cause serious human infections under specific circumstances, typically involving changes in the gut environment and/or host immune conditions. Therefore, utilizing animal models of fungal GI colonization and dissemination can lead to significant insights into the complex pathophysiology of transformation from a commensal organism to a pathogen and host-pathogen interactions. This paper will review the methodologic approaches used for modeling GI colonization versus dissemination, the insights learned from these models, and finally, possible future directions using these animal modeling systems.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Candida
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Candidíase
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Modelos Animais de Doenças
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Intestinos
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Camundongos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article